材料科学
光动力疗法
纳米材料
纳米技术
生物相容性材料
活性氧
异质结
光电子学
生物医学工程
化学
有机化学
生物化学
医学
作者
Meng Qiu,Dou Wang,Hao Huang,Teng Yin,Wenli Bao,Bin Zhang,Zhongjian Xie,Ni Xie,Zongze Wu,Chenchen Ge,Qi Wang,Meng Gu,Hilliard L. Kutscher,Liping Liu,Shaowen Bao,Paras N. Prasad,Han Zhang
标识
DOI:10.1002/adma.202102562
摘要
Optoelectronic science and 2D nanomaterial technologies are currently at the forefront of multidisciplinary research and have numerous applications in electronics and photonics. The unique energy and optically induced interfacial electron transfer in these nanomaterials, enabled by their relative band alignment characteristics, can provide important therapeutic modalities for healthcare. Given that nano-heterostructures can facilitate photoinduced electron-hole separation and enhance generation of reactive oxygen species (ROS), 2D nano-heterostructure-based photosensitizers can provide a major advancement in photodynamic therapy (PDT), to overcome the current limitations in hypoxic tumor microenvironments. Herein, a bismuthene/bismuth oxide (Bi/BiOx)-based lateral nano-heterostructure synthesized using a regioselective oxidation process is introduced, which, upon irradiation at 660 nm, effectively generates 1 O2 under normoxia but produces cytotoxic •OH and H2 under hypoxia, which synergistically enhances PDT. Furthermore, this Bi/BiOx nano-heterostructure is biocompatible and biodegradable, and, with the surface molecular engineering used here, it improves tumor tissue penetration and increases cellular uptake during in vitro and in vivo experiments, yielding excellent oxygen-independent tumor ablation with 660 nm irradiation, when compared with traditional PDT agents.
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