氧化应激
伤口愈合
炎症
活性氧
PI3K/AKT/mTOR通路
脂质过氧化
医学
蛋白激酶B
糖尿病
细胞凋亡
药理学
癌症研究
化学
免疫学
细胞生物学
生物
内科学
内分泌学
生物化学
作者
Shuangwen Li,Yuan Li,Ziyu Wu,Zhongming Wu,Zhongming Wu,Zhongming Wu,Hongjuan Fang
出处
期刊:American Journal of Physiology-endocrinology and Metabolism
[American Physiological Society]
日期:2021-08-23
卷期号:321 (4): E509-E520
被引量:105
标识
DOI:10.1152/ajpendo.00042.2021
摘要
Ferroptosis-related characteristic changes were found in diabetic wound models. Inhibition of ferroptosis improved inflammatory infiltration of diabetic wounds. PI3K/AKT signal pathway was rescued by restraining of ferroptosis. Mitigation of ferroptosis in diabetic wound promoted the wound healing.
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