基因组
微生物群
计算生物学
生物
人类健康
肠道菌群
代谢组学
人体微生物群
肠道微生物群
基因组
酶
生物信息学
生物技术
生物化学
基因
医学
环境卫生
作者
Baolei Jia,Han Xiao,Kyung Hyun Kim,Che‐Ok Jeon
标识
DOI:10.1016/j.tibtech.2021.06.008
摘要
Advances in technological and bioinformatics approaches have led to the generation of a plethora of human gut metagenomic datasets. Metabolomics has also provided substantial data regarding the small metabolites produced and modified by the microbiota. Comparatively, the microbial enzymes mediating the transformation of metabolites have not been intensively investigated. Here, we discuss the recent efforts and technologies used for discovering and mining enzymes from the human gut microbiota. The wealth of knowledge on metabolites, reactions, genome sequences, and structures of proteins, may drive the development of strategies for enzyme mining. Ongoing efforts to annotate gut microbiota enzymes will explain catalytic mechanisms that may guide the clinical applications of the gut microbiome for diagnostic and therapeutic purposes.
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