单线态氧
光化学
光动力疗法
化学
紧身衣
三重态
三聚体
单重态
活性氧
单重态裂变
氧气
激发态
荧光
激进的
超氧化物
分子
有机化学
二聚体
原子物理学
物理
酶
量子力学
生物化学
作者
Kun‐Xu Teng,Wenkai Chen,Li‐Ya Niu,Wei‐Hai Fang,Ganglong Cui,Qing‐Zheng Yang
标识
DOI:10.1002/anie.202106748
摘要
Developing Type-I photosensitizers is considered as an efficient approach to overcome the deficiency of traditional photodynamic therapy (PDT) for hypoxic tumors. However, it remains a challenge to design photosensitizers for generating reactive oxygen species by the Type-I process. Herein, we report a series of α,β-linked BODIPY dimers and a trimer that exclusively generate superoxide radical (O2-. ) by the Type-I process upon light irradiation. The triplet formation originates from an effective excited-state relaxation from the initially populated singlet (S1 ) to triplet (T1 ) states via an intermediate triplet (T2 ) state. The low reduction potential and ultralong lifetime of the T1 state facilitate the efficient generation of O2-. by inter-molecular charge transfer to molecular oxygen. The energy gap of T1 -S0 is smaller than that between 3 O2 and 1 O2 thereby precluding the generation of singlet oxygen by the Type-II process. The trimer exhibits superior PDT performance under the hypoxic environment.
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