尾部悬挂试验
行为绝望测验
抗抑郁药
抗焦虑药
兴奋剂
习得的无助感
药理学
5-HT2C受体
褪黑素
受体
受体拮抗剂
褪黑激素受体
血清素
内科学
化学
内分泌学
5-羟色胺受体
敌手
医学
部分激动剂
5-HT7受体
5-HT1A受体
生物
心理学
发展心理学
海马体
作者
Nana Gao,Wei Zheng,Tiliwaerde Murezati,Wei Gu,Xiaorong Li,Zeng-liang Jin
摘要
To evaluate the antidepressant-like effect of compound GW117 in rodents using in vitro binding and uptake assays as well in vivo behavioral tests.We investigated the target profile of GW117 using [35 S]-GTPγS and [3 H]PIP binding. Using the forced swimming test and chronic unpredictable stress in rats, tail suspension test in mice and rats, and learned helplessness model in mice, we further revealed the antidepressant-like and anxiolytic-like effects of GW117.The current study suggests that GW117 displays serotonin 2C (5-HT2C ) receptor antagonist and melatonin type 1 and 2 (MT1 /MT2 ) receptor agonist properties, as well as evident antidepressant and anxiolytic effects.These data suggest that GW117 is probably a potent antidepressant.
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