一氧化氮
抗菌剂
化学
分子
生物物理学
抗生素
部分
溶血
万古霉素
药物输送
金黄色葡萄球菌
组合化学
细菌
生物化学
一氧化碳
立体化学
有机化学
医学
生物
催化作用
免疫学
遗传学
作者
Jinming Hu,Lei Gao,Jian Cheng,Zhiqiang Shen,Guoying Zhang,Shiyong Liu
标识
DOI:10.1002/anie.202112782
摘要
The local delivery of gaseous signaling molecules (GSMs) has shown promising therapeutic potential. However, although GSMs have a subtle interplay in physiological and pathological conditions, the co-delivery of different GSMs for therapeutic purposes remains unexplored. Herein, we covalently graft a nitric oxide (NO)-releasing N-nitrosamine moiety onto the carbon monoxide (CO)-releasing 3-hydroxyflavone (3-HF) antenna, resulting in the first NO/CO-releasing donor. Under visible light irradiation, photo-mediated co-release of NO and CO reveals a superior antimicrobial effect toward Gram-positive bacteria with a combination index of 0.053. The synergy of NO and CO hyperpolarizes and permeabilizes bacterial membranes, which, however, shows negligible hemolysis and no evident toxicity toward normal mammalian cells. Moreover, the co-release of NO and CO can efficiently treat MRSA infection in a murine skin wound model, showing a better therapeutic capacity than vancomycin.
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