VEGFR2 inhibition hampers breast cancer cell proliferation <i>via</i> enhanced mitochondrial biogenesis

VEGF enhances cancer cell proliferation by decreasing Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis, ROS production, and cell apoptosis. These findings suggested the anticancer potential of Ki8751 via increased mitochondrial biogenesis and ROS production.