自愈水凝胶
纳米复合材料
无定形磷酸钙
镁
纳米颗粒
壳聚糖
抗压强度
化学工程
材料科学
化学
钙
纳米技术
高分子化学
复合材料
有机化学
冶金
工程类
作者
Yingqi Chen,Cairong Li,Zhenming Wang,Jing Long,Ruiqi Wang,Jin Zhao,Wanze Tang,Yu Zhao,Ling Qin,Songlin Peng,Yuxiao Lai
标识
DOI:10.1016/j.apmt.2021.101182
摘要
The repair of critical-sized bone defects remains challenging. Natural polysaccharide-based hydrogels (NPHs) have shown great promise for facilitating bone defect healing, but limited by osteogenesis, mechanical strength and stability. Here we prepared a water-soluble methacrylic anhydride-co-phosphate modified chitosan (CSMAP) incorporated MgO nanoparticles to form a pergel, and followed by introduction of acrylamide to construct a double-network hydrogel (CSMAP-MgO). We found that Mg2+ released from CSMAP-MgO hydrogel in a stable and sustained manner in 30 days and the compressive strength was maintained and the compressive modulus was even enhanced during immersion in PBS for 28 days. Moreover, the CSMAP-MgO hydrogel was superior in promoting in vitro calcium phosphate deposition, MC3T3-E1 cell proliferation, osteogenic differentiation, and mineralization compared to Magnesium free groups. At 12 weeks post-implantation into a rat critical-sized calvarial defect, the CSMAP-MgO hydrogel promoted significantly more new bone formation compared to CSMAP and non-treated groups. Thus, the CSMAP-MgO hydrogel has great promising as a bone filling material.
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