A network pharmacology study on the Cervix Prescription for treatment of Cervical Cancer

Abstract Purpose: Based on the method of network pharmacology to explore the mechanism of the Cervical Prescription(CP) in the treatment of cervical cancer(CC) . Methods: To obtain the active ingredients and potential targets of CP from the Traditional Chinese Medicine Systems Pharmacology database and analysis platform (TCMSP) ; To search for targets related to cervical cancer through the database, and map the CP and the targets; Screen the core Targets, a Chinese medicine compoundtarget network and STRING database was used to construct a protein-protein interaction network (PPI). The DAVID 6.8 online tool was used to perform gene ontology (GO) and kyoto encyclopedia of genes and genome (KEGG) pathway enrichment analyses of overlapping targets. Results: The CP contains 2 active ingredients, corresponding to 301 non-reactive targets; 10 GO biological process related items and 73 signal pathways were obtained. Conclusion: By constructing a network diagram of "components-targets-pathways", 1Project fund: Zhejiang Provincial Natural Science Foundation Project(CN) (LQ20H270016); Zhejiang Traditional Chinese Medicine Administration (CN) (2020ZB087). *Profile of the author: Zhu Yingping, (1987-), female, attending physician, from Ganzhou, Jiangxi Province, master's degree student, research direction: Chinese medicine prevention and treatment of gynecological malignancies; E-mail: zhuyingping_26@126.com this study revealed that CP can exert its efficacy through multiple components, multiple targets, and multiple pathways to achieve the purpose of preventing and treating CC.The network pharmacology-based approach in the present study showed promising potential for identifying the main therapeutic targets from TCM formulas. This study provides valuable information for TCM researchers and clinicians to better understand the main therapeutic targets and therapeutic roles of herbal decoctions in clinical settings.