清醒
神经科学
睡眠剥夺
警惕(心理学)
齿状回
睡眠(系统调用)
皮质(解剖学)
昼夜节律
心理学
大脑皮层
睡眠神经科学
脑电图
中枢神经系统
计算机科学
操作系统
作者
Lukas B. Krone,Tomoko Yamagata,Cristina Blanco‐Duque,Mathilde C. C. Guillaumin,Martin Kahn,Vincent van der Vinne,Laura E McKillop,Shu K. E. Tam,Stuart N. Peirson,Colin J. Akerman,Anna Hoerder‐Suabedissen,Zoltán Molnár,Vladyslav V. Vyazovskiy
标识
DOI:10.1038/s41593-021-00894-6
摘要
Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis. The conventional view is that the cortex generates brain oscillations, while subcortical structures control global sleep–wake switching. This study shows that the cortex plays an important role in both global state control and sleep homeostasis.
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