石墨烯
氧化物
干细胞
纳米技术
化学
业务
材料科学
细胞生物学
生物
有机化学
作者
Nélson Durán,Ângela Cristina Malheiros Luzo,J. C. Souza,Wagner José Fávaro,Paula García,Nelsón Durán
出处
期刊:Current Molecular Medicine
[Bentham Science]
日期:2018-04-09
卷期号:17 (9): 619-626
被引量:10
标识
DOI:10.2174/1566524018666180308111915
摘要
Graphene and graphene oxide topography have an effect on the fate of stem cells such as adhesion, differentiation, and proliferation. This overview clearly shows that a new design and manipulation of associated graphene oxide stem cell culture platforms are of paramount importance as a focus in stem cell to tissue engineering applications. This overview also proposes that a film of graphene oxide is an efficient platform to modulate structure and function of multipotent mesenchymal stem/stromal cells (MSCs) and in special human adipose tissue derived mesenchymal stromal/stem cells (AT-MSCs). The implication of graphene oxide on osteogenesis, neurogenesis, oligodendrogenesis, adipogenic and epithelial differentiation is also discussed. Graphene oxide toxicity on stem cells and the importance of GO application on ATMSCs differentiation and proliferation are final topics that are being discussed. Keywords: Stem cells, graphene oxide, adipose tissue derived mesenchymal stromal/stem cells, topography, differentiation, tissue engineering.
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