Conjugation of Porphyrin to Nanohybrid Cerasomes for Photodynamic Diagnosis and Therapy of Cancer

Shining light on cancer cells: A cerasomal photosensitizer of high stability and loading efficiency was developed by conjugation of a porphyrin molecule to an organoalkoxysilylated lipid followed by sol–gel and self-assembly processes (see picture). This nanoformulation showed intrinsic fluorescence and significant damage to tumor cells under photoirradiation.