医学
乳腺癌
癌胚抗原
内科学
生物标志物
肿瘤科
癌症
接收机工作特性
阶段(地层学)
CA15-3号
淋巴结
曲线下面积
胃肠病学
古生物学
生物化学
化学
生物
作者
Wende Hao,Xuhui Zhang,Bingshui Xiu,Xinglun Yang,Shuofeng Hu,Zhiqiang Liu,Cuimi Duan,Sun Jin,Xiaomin Ying,Yanfeng Zhao,Han Xiao,Xiaopeng Hao,Yawen Fan,Heather Johnson,Di Meng,Jenny L. Persson,Heqiu Zhang,Xiaoyan Feng,Yan Huang
出处
期刊:Tumor Biology
[SAGE]
日期:2016-01-11
卷期号:37 (7): 8909-8916
被引量:10
标识
DOI:10.1007/s13277-015-4750-y
摘要
Breast cancer is the most common cancer in women worldwide, identification of new biomarkers for early diagnosis and detection will improve the clinical outcome of breast cancer patients. In the present study, we determined serum levels of vitronectin (VN) in 93 breast cancer patients, 30 benign breast lesions, 9 precancerous lesions, and 30 healthy individuals by enzyme-linked immunosorbent assays. Serum VN level was significantly higher in patients with stage 0–I primary breast cancer than in healthy individuals, patients with benign breast lesion or precancerous lesions, as well as those with breast cancer of higher stages. Serum VN level was significantly and negatively correlated with tumor size, lymph node status, and clinical stage (p < 0.05 in all cases). In addition, VN displayed higher area under curve (AUC) value (0.73, 95 % confidence interval (CI) [0.62–0.84]) than carcinoembryonic antigen (CEA) (0.64, 95 % CI [0.52–0.77]) and cancer antigen 15-3 (CA 15-3) (0.69, 95 % CI [0.58–0.81]) when used to distinguish stage 0–I cancer and normal control. Importantly, the combined use of three biomarkers yielded an improvement in receiver operating characteristic curve with an AUC of 0.83, 95 % CI [0.74–0.92]. Taken together, our current study showed for the first time that serum VN is a promising biomarker for early diagnosis of breast cancer when combined with CEA and CA15-3.
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