多细胞生物
机制(生物学)
生物化学
化学
计算生物学
药物发现
生物途径
生物活性
酶
戒毒(替代医学)
生物
基因
体外
基因表达
医学
认识论
哲学
病理
替代医学
作者
Eli Chapman,Michael D. Best,Sarah R. Hanson,Chi Huey Wong
标识
DOI:10.1002/anie.200300631
摘要
The sulfonation (also known as sulfurylation) of biomolecules has long been known to take place in a variety of organisms, from prokaryotes to multicellular species, and new biological functions continue to be uncovered in connection with this important transformation. Early studies of sulfotransferases (STs), the enzymes that catalyze sulfonation, focused primarily on the cytosolic STs, which are involved in detoxification, hormone regulation, and drug metabolism. Although known to exist, the membrane-associated STs were not studied as extensively until more recently. Involved in the sulfonation of complex carbohydrates and proteins, they have emerged as central players in a number of molecular-recognition events and biochemical signaling pathways. STs have also been implicated in many pathophysiological processes. As a result, much interest in the complex roles of STs and in their targeting for therapeutic intervention has been generated. Progress in the elucidation of the structures and mechanisms of sulfotransferases, as well as their biological activity, inhibition, and synthetic utility, are discussed in this Review.
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