Functional MRI Study Using ReHo of the Brain Activity in Idiopathic Generalized Epilepsy

Epilepsy is a common neurological disorder characterized by abnormal hyper-synchronization of neural activity.In this study,a data processing technology of rest-state fMRI,named regional homogeneity(ReHo) was used to investigate idiopathic generalized epilepsy(IGE).ReHo maps of each patients and healthy controls were generated respectively.Compared to the controls,the patients exhibited decreased ReHo mainly in the precuneus,medial prefrontal cortex,bilateral middle temporal gyrus and middle frontal gyrus;while the increased ReHo was mainly distributed in the subthalamus.The results indicate that ReHo can detect the abnormal regional homogeneity of the BOLD signals caused by epilepsy,and may be helpful for look into the pathophysiological mechanism of idiopathic generalized epilepsy.