Objective To evaluate the feasibility and stability of the application of active fixation leads with right ventricular septum pacing.Methods One hundred and sixty patients were divided into two groups randomly,80 patients each group.An active fixation lead was positioned in right ventricular septum(for groupⅠ)and a passive lead was placed in right ventricular apex(for group Ⅱ).Both the time for leads planting and the width of the QRS waves were recorded.Then pacing thresholds,sensation,impedances,lead dislocation and its complications were compared at 1,3,and 6 months after the operation.Results Group Ⅰ took more time to plant leads and expose in X-ray than group Ⅱ(26.34±6.54 min vs 20.86±4.32 min,16.78±5.38 min vs 8.67±4.52 min;all P0.01).At 15 minutes after the active fixation lead was planted,the pacing threshold dropped dramatically compared with the one done immediately(0.76±0.21 mV vs 1.12±0.25 mV,P0.01).The width of the QRS wave of group Ⅰ was narrower than that of group Ⅱ(0.14±0.04 ms vs 0.16±0.03 ms,P0.01).There was no significant difference in the pacing threshold between the two groups,and no patient was found whose lead was extracted.Conclusions The usage of active fixation lead in patients with ventricular septum pacing is feasible and steady.