Synthesis of Substituted Salicylaldehyde Arylsulfonyl-hydrazone Compounds and Their Scavenging Capacity on Hydroxyl Free Radical

Objective:To synthesize the substituted salicylaldehyde arylsulfonyl-hydrazone compounds,and to study their scavenging capacity for hydroxyl free radical(·OH).Method:Three substituted salicylaldehyde arylsulfonyl-hydrazone compounds were systhesized from benzenesulfonylhydrazine and substituted salicylaldehyde,and depending on orthophenanthroline-Fe(Ⅱ)method,the scavenging capacity on ·OH was detected by spectrophotometry.Results:The target compounds could effectively scavenge ·OH,but the capacity was inferior to vitamine C.Conclusion:The synthesized substituted salicylaldehyde arylsulfonyl-hydrazone compounds can scavenge ·OH and the activity can be increased by introducing the halogen group to the benzene ring of salicylaldehyde.