Objective To observe the threpautic effect of Naoan capsule on magraine. Methods 83 patients with magraine were randomly divided into two groups. 41 patients in treatment group were treated with Naoan capsule combined with Xibiling capsule;42 patients in control group were treated with only Naoan capsule,with a treatment course of 4 weeks for both groups.Results The cure rate and total effective rate were 58.54% and 92.68% in treatment group,compared with 23.81% and 64.29% in control group,there was a significant difference between two groups (P0.05). Conclusion Naoan capsule is effective in the treatment of magraine,with less side effects,which is convenient to be taken and easy to be popularized.