Non-tumor cells in tumor microenvironment

Tumor microenvironment is a spatial structure including many kinds of cells and stroma around them,which interact each other to form a variety of crosstalks.Current research confirms that tumor progress and metastasis are involved in autocrine and paracrine by peritumor cells,which create a robust system that can regulate their response to treatment.Non-tumor cells in tumor environment play a crucial role.Proposed here is the therapy for cancer treatment,which could be more effective in destruction of the tumor microenvironment than just killing the tumor cells.