Study on the Ciprofloxacin Polyactic Acid Microspheres

AIM:To optimize the preparation technology of ciprofloxacin polylactic acid microspheres through orthogonal test. METHOD:The orthogonal test design was used to optimize the technology of preparation. The surface morphology of the microspheres was observed by SEM. The formation of ciprofloxacin microspheres was confirmed by DSC. The mean diameter and the size distribution of microspheres,the drug leading,the incorporation efficiency,the reappearances of pharmaceutical technology were examined. RESULT:The ciprofloxacin polylactic acid microspheres were regular in their morphology. Ciprofloxacin was enveloped in microspheres and not physically mixed with polylactic acid. The average particle size of microspheres was 280.80±0.15 μm with over 90% of the microspheres being in the range of 250～390 μm;the drug loading and the incorporation efficiency were (34.1±0.51)% and (65.7±0.58)% respectively. The reappearance of pharmaceutical technology was good. CONCLUSION: This paper described the optimized preparation technology of ciprofloxacin polylactic acid microspheres.