Experiment research of avascular necrosis of the femoral head after ligating different blood vessels supplying femoral head by bone imaging of ~(99m)Tc-MDP and quantitative analysis

Objective To observe the viability of blood flow after ligating different blood vessels supplying femoral head and to provide basis for choosing different treatment of avascular necrosis of femoral head(ANFH).Methods The rabbits were divided into A,B and C group,and their medial or lateral femoral circumflex arteries were ligated.The radioactive count of experimental femoral head(E_(head)),experimental femoral shaft(E_(shaft)),control femoral head(C_(head))and control femoral shaft(C_(shaft))of rabbits were measured by single photon emission computed tomugraphy in the second hour,the third day,the fourth week and the eighth week after operation.Results C_(head)/C_(head) is 2.72.E_(head)/C_(head) and E_(head)/E_(shaft) of A and B groups decreased distinctively,no significant difference was found between these two groups(P0.05).E_(head)/C_(head) and E_(head)/E_(shaft) of C group decreased indistinctivly,significant difference were found between C group and A or B groups(P0.05).Conclusion The viability of blood flow could be observed,bone imaging of()~(99m)Tc-MDP and quantitative analysis could provide conductive significance for diagnosis,treatment and prognosis of ANFH.