Effects of Estrogen on Bcl-2 and Bax of Uterus in Ovariectomized Rats

This study was designed to know the effects of estrogen on apoptosis of uterus tissue,using the method of immuno-histochemical SP to investigate the Bcl-2 and Bax positive expressions in uterus of rats ovariectomized and treated with 17β-estrodiol in five different dosage periods.The result showed that the ovariectomized group(the group OVX) had very significantly degrade with the group of ovariectomized and treated with 17β-estrodiol(the group OVX+E2) on expressions of Bcl-2 within the same stage(P0.01),while expressions of Bax had significantly upgrade(P0.05);the expressions of Bcl-2 and Bax of the sham ovariectomized group(the group SHAM) and the group OVX+E2 in different periods had no remarkable difference.In the later stage,the positive expressions of Bcl-2 had a slight increase than before in the group OVX,while the expressions of Bax were decreasing,and the expressions had no remarkable difference.All the results illustrated that estrogen in proper dose had certain protective effect on uterus by up-regulating the expressions of Bcl-2 and down-regulating the expressions of Bax in the initial stage of estrogen deficiency,while no significant regulative effect in the later stage of estrogen deficiency.