Objective To analyze the correlations between direct nursing hours with the the severity of illness and therapeutic intervention in ICU.Method Fifty-three patients whose score of APACHE Ⅱ was over 9 points were recruited by convenient sampling method.The score of APACHE II,Therapeutic Intervention Scoring System TISS-28 and direct nursing hours were recorded and measured.Results There were significant differences in the direct nursing hours among patients with different disease severity,as well as the index of TISS-28.The correlation coefficient was 0.497 between direct nursing hours with APACHE II and 0.690 with TISS-28.Conclusions The direct nursing hours are correlated with the severity of illness and therapeutic intervention.It is suggested to predict nursing workload and nurse staffing based on the evaluation of TISS-28.