Based on the basic theories of ergonomics,relevant documents and statistics,related factors which affect the safety of human-machine interface are analysed.It is proved that the human-machine interface is an important part in industrial equipment system and the security setting and performance of it plays a significant influence on safe operation of industrial equipments.However,it is both monitor and controller that determine the safety of man-machine interface.Therefore,the setting of human-machine interface should take the personnel's behavioral and psychological characteristics into consideration.