Objective To observe the clinical effect of Duhuojisheng decoction in the treatment of rheumatoid arthritis. Methods 69 patients with rheumatoid arthritis were collected from July 2013 to July 2014 in our hospital, and were divided into control group and study group according to different treatment methods. 35 patients in the study group were given Duhuojisheng decoction treatment, while, 34 patients in the control group were given western medicine treatment. And then observed and compared the treatment efficacy of the two groups. Results The study group had higher treatment efficiency compared with control group, and with significant difference between the two groups(P0.05). Conclusion Duhuojisheng decoction treatment has effect to treat patients with rheumatoid arthritis.