Effect of mecobalamin treatment on the recovery of patients with posterior communicating artery aneurysm inducing oculomotor nerve palsy after operation.

OBJECTIVE: This research aims to evaluate the effect of mecobalamin treatment on the recovery of patients with posterior communicating artery aneurysm inducing oculomotor nerve palsy after embolization. PATIENTS AND METHODS: A total of 56 patients with oculomotor nerve palsy (ONP) attributed to posterior communicating artery (PcomA), were admitted and treated in the Neurology Department of Hubei College of Medicine affiliated to Xiangyan Hospital from July 2007 to January 2013, and 55 of them were followed up as well. Among them 27 patients were given embolization treatment and 28 received embolization + mecobalamin treatment. The recovery condition of ONP were followed and compared one year after the treatment. RESULTS: All patients were followed up for more than a year. And 31 patients (56.4%) out of 55 achieved complete recovery, 19 (34.5%) attained partial recovery and 5 (9.1%) had no recovery from ONP. Whereas, 20 patients (71.4%) in the embolization + mecobalamin treatment group achieved complete recovery and 11 (40.7%) in the embolization treatment group achieved partial recovery, and the comparative difference was statistically significant (p < 0.05). CONCLUSIONS: Endovascular is highly efficacious treatment for ONP-inducing PcomA and can promote the recovery of oculomotor nerve palsy after embolism.