The biosafety of laboratory involves in many subjects fields,and it a work with strong practicality operation.As laboratory's biosafety the related scientific research developing fast in China,the laboratory staff's knowledge about biological safety should be enriched the skills of practices should be improved.The Technical Specification for Construction of Biosafety is a very important,practical standard document of constructing biosafety laboratory in China.General Biosafety Guidelines for Microorganism Biological Medical Laboratories Biosafety Requirements for Laboratory which made detailed standards for laboratory's installations of different safety levels,are the major basis for construction transformation of biosafety laboratory.Regulations on Biosafety Administration in Pathogenic Microbiology and General Biosafety Requirements for Laboratory are also the important basis for managing the activities making rules regulations of biosafety laboratory.The implementation of laboratory biosafety risk assessment,determination of laboratory's grade individual protective equipment,and development of related operation rules emergency measures can reduce or avoid the incident of laboratory infection.The safety of laboratory associated with management.Only the strict management standard operation can ensure the safe operation of laboratory.