医学
止痛药
阿片类药物过量
类阿片
药物过量
麻醉
重症监护医学
医疗急救
毒物控制
(+)-纳洛酮
内科学
受体
作者
Edoardo Picetti,Ilaria Rossi,Maria Luisa Caspani
摘要
Opioid analgesic overdose is a preventable and potentially lethal condition that results from prescribing practices, inadequate understanding on the patient's part of the risks of medication misuse, errors in drug administration, and pharmaceutical abuse. 1,2Three features are key to an understanding of opioid analgesic toxicity.First, opioid analgesic overdose can have life-threatening toxic effects in multiple organ systems.Second, normal pharmacokinetic properties are often disrupted during an overdose and can prolong intoxication dramatically. 3Third, the duration of action varies among opioid formulations, and failure to recognize such variations can lead to inappropriate treatment decisions, sometimes with lethal results. 2,4
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