A systematic overview of the strategies adopted (microbial, enzymatic and chemical pathways) in prior arts towards the synthesis of renowned anti-fibrinolytic drug, Tranexamic acid

This review initiative was intended to provide insights on the state of art details about the synthesis of popular drug, Tranexamic acid TnA. Tranexamic acid is the name given to trans-isomer of 4-aminomethylcyclohexane carboxylic acid (AMCCA). With regard to anti-fibrilolytic activity, TnA was found to be active but cis-AMCCA was inactive. The molecular framework and the associated stereochemistry of TnA has been the bottleneck for its preparation and isolation with ease. Many scientific communications were disclosed as journal articles or patents regarding the synthesis of TnA and its related scaffolds. Upon examination of these disclosures, we could able to observe the efforts of scientists to empower the synthetic routes to be commercially viable and scalable. In line with these aspects, the microbial and enzymatic pathways were not given the priority. For the ease of better clarity, the disclosed reaction schemes were reframed (Scheme 1-18) and the improvements attained in each research work were highlighted.