Stereoselective Domino Reactions in the Synthesis of Spiro Compounds

Abstract This review summarizes the latest developments in asymmetric domino reactions, with the emphasis on the preparation of spiro compounds. Discussions on the stereoselectivity of the transformations, the reaction mechanisms, the rationalization of the stereochemical outcome, and the applications of domino reactions to the synthesis of biologically active molecules and natural products are included when appropriate. 1 Introduction 2 Asymmetric Domino Reactions 2.1 Domino Reactions Initiated by Michael Reactions 2.2 Domino Reactions Initiated by Mannich Reactions 2.3 Domino Reactions Initiated by Knoevenagel Reactions 2.4 Domino Reactions Initiated by Cycloaddition Reactions 2.5 Domino Reactions Initiated by Metal Insertion 2.6 Other Mechanisms 3 Conclusion