Acute myeloid leukaemia

Acute myeloid leukaemia accounts for 15-20% of paediatric leukae-mia. This chapter describes the epidemiology, clinical features, inves-tigation, diagnosis and classification of acute myeloid leukaemia in children. Treatment with intensive chemotherapy and (in some chil-dren) haemopoietic stem cell transplantation, treatment complications and prognosis are described. Acute promyelocytic leukaemia in chil-dren and Down syndrome-acute myeloid leukaemia are also discussed briefly.