芳基
烷基
化学
羰基化
卤化物
氯甲酸盐
电泳剂
氯甲酸乙酯
还原消去
卤代芳基
催化作用
组合化学
偶联反应
镍
有机化学
一氧化碳
作者
Haifeng Chen,Huifeng Yue,Chen Zhu,Magnus Rueping
标识
DOI:10.1002/anie.202204144
摘要
Abstract The nickel‐catalyzed three‐component reductive carbonylation of alkyl halides, aryl halides, and ethyl chloroformate is described. Ethyl chloroformate is utilized as a safe and readily available source of CO in this multi‐component protocol, providing an efficient and practical alternative for the synthesis of aryl‐alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Experimental and DFT mechanistic studies highlight the complexity of the cross‐electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate, and alkyl halide.
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