丙型肝炎病毒
肝细胞癌
分子印迹聚合物
肝硬化
化学
电化学气体传感器
丙型肝炎
分子印迹
肝病
肝癌
病毒学
电化学
病毒
电极
选择性
催化作用
生物化学
癌症研究
医学
内科学
物理化学
作者
Mariia Antipchik,Jekaterina Reut,Akinrinade George Ayankojo,Andres Öpik,Vitali Syritski
出处
期刊:Talanta
[Elsevier]
日期:2022-12-01
卷期号:250: 123737-123737
被引量:16
标识
DOI:10.1016/j.talanta.2022.123737
摘要
Hepatitis C is the most common liver disease caused by Hepatitis C virus (HCV), and can evolve into serious health problems e.g. cirrhosis and hepatocellular carcinoma. Nowadays, the initial stage of the disease cannot be practically diagnosed, representing thus an extremely important problem of modern public health care. This study is aimed at the development of a sensor for direct detection of HCV. The sensor utilizes a synthetic recognition element prepared by the technology of molecular imprinting and representing a molecularly imprinted polymer (MIP) having molecular recognition sites of HCV envelope protein E2 (E2-MIP). E2-MIP integrated into an electrochemical sensor platform allows quantitative evaluation of binding of free E2 protein as well as HCV-mimetic particles (HCV-MPs) in human plasma with LOD value of 4.6 × 10-4 ng/mL (for HCV-MPs). The developed electrochemical HCV sensor represents a simple, fast and inexpensive alternative for the existing methods of HCV detection and paves the way for the point-of care diagnostics of Hepatitis C.
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