生物
肿瘤微环境
间质细胞
计算生物学
转移
肿瘤细胞
癌症
鉴定(生物学)
癌症研究
癌细胞
肿瘤进展
作者
Rolando Vegliante,Ievgenia Pastushenko,Cédric Blanpain
标识
DOI:10.15252/embj.2021109221
摘要
Within a tumor, cancer cells exist in different states that are associated with distinct tumor functions, including proliferation, differentiation, invasion, metastasis, and resistance to anti-cancer therapy. The identification of the gene regulatory networks underpinning each state is essential for better understanding functional tumor heterogeneity and revealing tumor vulnerabilities. Here, we review the different studies identifying tumor states by single-cell sequencing approaches and the mechanisms that promote and sustain these functional states and regulate their transitions. We also describe how different tumor states are spatially distributed and interact with the specific stromal cells that compose the tumor microenvironment. Finally, we discuss how the understanding of tumor plasticity and transition states can be used to develop new strategies to improve cancer therapy.
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