脂肪性肝炎
脂肪变性
化学
脂肪肝
甾醇调节元件结合蛋白
高脂血症
甘油三酯
以兹提米比
微粒体甘油三酯转移蛋白
生物化学
内科学
内分泌学
胆固醇
医学
甾醇
极低密度脂蛋白
脂蛋白
糖尿病
疾病
作者
Liming Zhou,Jie Fan,Minmin Xu,Meng-Yuan Xiong,Qiao-Jiao Wang,Xue Chai,Xiao-Duo Li,Xuegang Li,Xiaoli Ye
标识
DOI:10.1016/j.bbadis.2023.166639
摘要
Epiberberine (EPI), extracted from Rhizome Coptidis, has been shown to attenuate hyperlipidemia in vivo. Herein we have studied the mechanism by which EPI is active against non-alcoholic steatohepatitis (NASH) using, mice fed on a methionine- and choline-deficient (MCD) diet and HepG2 cells exposed to free fatty acids (FFA). We show that small heterodimer partner (SHP) protein is key in the regulation of lipid synthesis. In HepG2 cells and in the livers of MCD-fed mice, EPI elevated SHP levels, and this was accompanied by a reduction in sterol regulatory element-binding protein-1c (SREBP-1c) and FASN. Therefore, EPI reduced triglyceride (TG) accumulation in steatotic hepatocytes, even in HepG2 cells treated with siRNA-SHP, and also improved microbiota. Thus, EPI suppresses hepatic TG synthesis and ameliorates liver steatosis by upregulating SHP and inhibiting the SREBP1/FASN pathway, and improves gut microbiome.
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