Supporting Figures S5-S8 from Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer
作者
Suriyan Ponnusamy,Christopher C. Coss,Thirumagal Thiyagarajan,Kate Watts,Dong‐Jin Hwang,Yali He,Luke A. Selth,Iain J. McEwan,C. B. Duke,Jayaprakash Pagadala,Geetika Singh,Robert Wake,Christopher Ledbetter,Wayne D. Tilley,Tudor Moldoveanu,James T. Dalton,Duane D. Miller,Ramesh Narayanan
<p>S5: UT-155 prevents nuclear localization of AR and AR v567es. S6: UT-155 binds to AR AF-1 domain. S7: Results from microarray with SARDs.S8: UT-155 inhibits transactivation of AD1 and D567es AR transactivation. Metabolism properties of SARDs.</p>
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(2025-6-4)
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