生酮饮食
酮症
医学
疾病
神经炎症
生物信息学
神经科学
不利影响
酮体
内科学
癫痫
内分泌学
糖尿病
生物
精神科
新陈代谢
作者
Haiyan Zhang,Ye Tao,Sean X. Leng
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2022-12-01
卷期号:20 (12): 2303-2319
被引量:13
标识
DOI:10.2174/1570159x20666220830102628
摘要
This review discusses the effects and mechanisms of a ketogenic diet on neurodegenerative diseases on the basis of available evidence. A ketogenic diet refers to a high-fat, mediumprotein, and low-carbohydrate diet that leads to a metabolic shift to ketosis. This review systematically summarizes the scientific literature supporting this effective treatment approach for neurodegenerative diseases, including effects on mitochondrial function, oxidative stress, neuronal apoptosis, neuroinflammation, and the microbiota-gut-brain axis. It also highlights the clinical evidence for the effects of the ketogenic diet in the treatment of Alzheimer's disease, Parkinson's disease, and motor neuron disease. Finally, it discusses the common adverse effects of ketogenic therapy. Although the complete mechanism of the ketogenic diet in the treatment of neurodegenerative diseases remains to be elucidated, its clinical efficacy has attracted many new followers. The ketogenic diet is a good candidate for adjuvant therapy, but its specific applicability depends on the type and the degree of the disease.
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