前药
姜黄素
PEG比率
喜树碱
药理学
化学
脂质体
肺癌
细胞凋亡
伊立替康
聚乙二醇
医学
癌症研究
癌症
生物化学
肿瘤科
内科学
结直肠癌
财务
经济
作者
Chengzhi Gao,Lanfang Zhang,Minhao Xu,Yi Luo,Ben Wang,Meiyan Kuang,Xingyou Liu,Min Sun,Yue Guo,Lesheng Teng,Chenhui Wang,Yan Zhang,Jing Xie
标识
DOI:10.1016/j.ejpb.2022.08.021
摘要
A co-delivery system of SN38 (7-ethyl-10-hydroxyl camptothecin) prodrug and CUR (curcumin) was designed for the treatment of lung cancer by pulmonary delivery. SN38 was linked to cell-penetrating peptide (CPP) TAT via a polyethylene glycol (PEG) linker to form the SN38 prodrug (TAT-PEG-SN38). Liposomes co-loaded with amphiphilic TAT-PEG-SN38 and curcumin (Lip-TAT-PEG-SN38/CUR) were successfully prepared by a microfluidic method for the treatment of lung cancer via pulmonary delivery. Lip-TAT-PEG-SN38/CUR showed nanometer-sized sphericity and a particle size of 171.21 nm. Besides, Lip-TAT-PEG-SN38/CUR exhibited enhanced antiproliferative effect, increased cell apoptosis induction and improved cell cycle arrest compared to the single agents in vitro. The combination induced significant tumor inhibition in a BALB/c mouse lung cancer model. These results indicated that our SN38 prodrug and curcumin co-delivery system was a promising candidate for lung cancer treatment.
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