Recent Advances in the Impact of Antibiotic and Antioxidant Multifunctional Hydrogel on Diabetic Wounds Healing

Abstract: Hyperglycemia is a metabolic illness characterized by diabetes mellitus. Chronic hyperglycemia can lead to infection, production of more reactive oxygen species, chronic inflammation, and impaired angiogenesis, thus increasing the wound’s healing time. As the diabetic wound healing process is a more complex pathology, the demand to develop a topical application has emerged. This review focuses on the diabetic wound, wound healing, and the factors that influence diabetic wound healing. It also highlights the impact of combination delivery of antibiotics and antioxidants loaded with multifunctional hydrogel on diabetic wound healing. Due to the immense financial strain caused by this pathology, there is a need for other effective novel methods for wound healing. Therefore, multifunctional hydrogels, which are effective and have been used mainly as a carrier system for diabetic wound treatment, have been studied. Hence, the application of antibiotics and antioxidants loaded with multifunctional hydrogel in treating diabetic wounds is reviewed. Hydrogels present a significant theoretical reference for diabetic wound healing.