结肠炎
多不饱和脂肪酸
氧化应激
炎症
六烯酸
二十碳五烯酸
炎症性肠病
内科学
化学
肝病
内分泌学
生物
生物化学
脂肪酸
医学
疾病
作者
Nadine Rohwer,Julia Jelleschitz,Annika Höhn,Daniela Weber,Anja A. Kühl,Chaoxuan Wang,Rei-ichi Ohno,Nadja Kampschulte,Anne Pietzner,Nils Helge Schebb,Karsten H. Weylandt,Tilman Grune
出处
期刊:Redox biology
[Elsevier]
日期:2023-08-01
卷期号:64: 102803-102803
被引量:3
标识
DOI:10.1016/j.redox.2023.102803
摘要
Inflammatory bowel disease (IBD) is an immune-mediated gut dysfunction, which might also be associated with an inflammatory phenotype in the liver. It is known that the nutritional intake of omega-3 polyunsaturated fatty acids (n-3 PUFA) is inversely correlated to the severity and occurrence of IBD. In order to investigate whether n-3 PUFA can also reduce liver inflammation and oxidative liver damage due to colon inflammation, we explored the dextran sulfate sodium (DSS)-induced colitis model in wild-type and fat-1 mice with endogenously increased n-3 PUFA tissue content. Besides confirming previous data of alleviated DSS-induced colitis in the fat-1 mouse model, the increase of n-3 PUFA also resulted in a significant reduction of liver inflammation and oxidative damage in colitis-affected fat-1 mice as compared to wild-type littermates. This was accompanied by a remarkable increase of established inflammation-dampening n-3 PUFA oxylipins, namely docosahexaenoic acid-derived 19,20-epoxydocosapentaenic acid and eicosapentaenoic acid-derived 15-hydroxyeicosapentaenic acid and 17,18-epoxyeicosatetraenoic acid. Taken together, these observations demonstrate a strong inverse correlation between the anti-inflammatory lipidome derived from n-3 PUFA and the colitis-triggered inflammatory changes in the liver by reducing oxidative liver stress.
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