纳米医学
材料科学
纳米技术
巨噬细胞极化
极化(电化学)
金属有机骨架
催化作用
金属
多孔性
巨噬细胞
化学
复合材料
纳米颗粒
有机化学
体外
冶金
吸附
物理化学
生物化学
作者
Feifei Wang,Hang Yao,Xinyue Wu,Yijian Tang,Yang Bai,Hui Chong,Huan Pang
标识
DOI:10.1016/j.cclet.2023.108821
摘要
Metal–organic framework (MOF) is a periodic sexual network structure with large surface area and high porosity, which is assembled by inorganic nodes and organic ligands through coordinate covalent bond. MOFs have the advantages of controllable pore size and shape, large specific surface area, easy modification and more active sites. In addition, MOF based nanoenzymes display excellent enzyme catalytic activity due to their special structure and multiple exposed metal active sites, controlling the production of reactive oxygen species (ROS) in cells or the body, and thus regulating the polarization of macrophage. This article reviews the mechanism of MOF material regulating macrophage polarization and the function of macrophages with different phenotypes. By utilizing the excellent properties of MOFs and the advantages of combining them with bioactive materials, we have discovered their excellent applications in the treatment of inflammatory diseases. Finally, we discussed the current challenges and prospects faced by MOF based composite materials. We expect that the research in this developing field will play a more important role in combating inflammatory diseases in the field of nanomedicine.
科研通智能强力驱动
Strongly Powered by AbleSci AI