孟德尔随机化
混淆
观察研究
疾病
医学
随机对照试验
随机化
妇女健康倡议
生物信息学
生物
内科学
遗传学
遗传变异
基因
基因型
作者
Tara Zeitoun,Ahmed El‐Sohemy
标识
DOI:10.3390/ijms241713458
摘要
Iron has been shown to play a dual role in health and disease, with either a protective or harmful effect. Some of the contradictory findings from observational studies may be due to reverse causation, residual confounding, or small sample size. One approach that may overcome these limitations without the high cost of randomized control trials is the use of Mendelian randomization to examine the long-term role of iron in a variety of health outcomes. As there is emerging evidence employing Mendelian randomization as a method of assessing the role of micronutrients in health and disease, this narrative review will highlight recent Mendelian randomization findings examining the role of iron in cardiometabolic disorders, inflammation, neurological disorders, different cancers, and a number of other health-related outcomes.
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