阿霉素
膀胱癌
透明质酸
癌症研究
癌症
光热治疗
材料科学
体内
药物输送
内吞作用
癌细胞
生物相容性
化疗
医学
纳米技术
内科学
生物
生物技术
受体
解剖
冶金
作者
Husen Qiu,Jianwu Wang,Yi Zhi,Binghai Yan,Yuandi Huang,Jinjin Li,Chongxing Shen,Linyong Dai,Qiang Fang,Shi Chen,Weibing Li
标识
DOI:10.1021/acsami.3c09564
摘要
Bladder cancer is one of the most common malignancies in the urinary system, with high risk of recurrence and progression. However, the difficulty in detecting small tumor lesions and the lack of selectivity of intravesical treatment seriously affect the prognosis of patients with bladder cancer. In the present work, a nanoparticle-based delivery system with tumor targeting, high biocompatibility, simple preparation, and the ability to synergize imaging and therapy was fabricated. Specifically, this nanosystem consisted of the core of doxorubicin (DOX)-loaded polydopamine nanoparticles (PDD NPs) and the shell of hyaluronic acid (HA)-conjugated IR780 (HA-IR780). The HA-IR780-covered PDD NPs (HR-PDD NPs) demonstrated tumor targeting and visualization both in vitro and in vivo with properties of promoted cancer cell endocytosis and lysosomal escape, efficiently delivering drugs to the target site and exerting a killing effect on tumor cells. Encouragingly, intravesical instillation of HR-PDD NPs improved drug retention in the bladder and promoted its accumulation in tumor tissue, resulting in better tumor proliferation inhibition and apoptosis in an orthotopic bladder cancer model in rats. This study provides a promising strategy for the diagnosis and therapy of bladder cancer.
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