表观遗传学
肠道菌群
重编程
DNA甲基化
生物
串扰
微生物群
结直肠癌
组蛋白
肠道微生物群
生物信息学
遗传学
癌症
免疫学
DNA
基因
基因表达
物理
光学
作者
A. B C Chen,Zhengting Jiang,Liquan Cai,Dong Tang
标识
DOI:10.1093/carcin/bgad058
摘要
Abstract An increasing number of studies have reported the role of gut microbes in colorectal cancer (CRC) development, as they can be influenced by dietary metabolism and mediate alterations in host epigenetics, ultimately affecting CRC. Intake of specific dietary components can affect gut microbial composition and function, and their metabolism regulates important epigenetic functions that may influence CRC risk. Gut microbes can regulate epigenetic modifications through nutrient metabolism, including histone modification, DNA methylation, and noncoding RNAs. Epigenetics, in turn, determines the gut microbial composition and thus influences the risk of developing CRC. This review discusses the complex crosstalk between metabolic reprogramming, gut microbiota, and epigenetics in CRC and highlights the potential applications of the gut microbiota as a biomarker for the prevention, diagnosis, and therapy of CRC.
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