白癜风
医学
发病机制
基质金属蛋白酶
白细胞介素
疾病
内科学
胃肠病学
免疫学
细胞因子
作者
Hamada Mashaly,Nahla S. Hunter,Olfat Shaker,Dina Dorgham,Shaiful Bahari Ismail
标识
DOI:10.1016/j.jid.2023.09.040
摘要
Background: Patients with vitiligo have disturbed melanосуtiс milieu either by rise or decline in levels of certain mediators. Objectives: The study aimed at measuring Matrix Metalloproteіnase-9 (MMP-9) and Interlcukіn-17 (IL-17) tissue levels in patients with stable, Non-Segmental Vialigo (NSV) and determining if there is any relation between their levels and patients' age and sex, and disease activity, extent and duration. Patients and Methods: Thirty patients with stable NSV were recruited. Punch skin biopsies were taken and examined by ELISA to detect the levels of MMP-9 and IL-17. Results: All cases with stable NSV had low MMP-9 and elevated IL-17 levels. None of them was related to the age, sex, disease activity and duration, and extent of vitiligo. Conclusion: Imbalance in MMP-9 and IL-17 levels is directly related to vitiligo pathogenesis and targeting these mediators could be a promising line of treatment.
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