化学
三氟甲基
串联
衍生化
组合化学
有机化学
烷基
材料科学
复合材料
高效液相色谱法
作者
Li Wu,Xia Liu,Zhao-Wen Liu,Z.‐C. Chen,Xiang Fu,Ke‐Fang Yang
摘要
We herein propose a HFIP-promoted tandem cyclization reaction for the synthesis of difluoro/trifluoromethyl carbinol-containing chromones from o-hydroxyphenyl enaminones at room temperature. This protocol provides a facile and efficient approach to access diverse difluoro/trifluoromethylated carbinols in good to excellent yields. In addition, gram-scale and synthetic derivatization experiments have also been performed.
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