血红素加氧酶
脊髓损伤
脊髓
成纤维细胞生长因子
血红素
成纤维细胞
细胞生物学
医学
化学
生物
神经科学
内科学
生物化学
受体
酶
体外
作者
Qi Gu,Weiping Sha,Qun Huang,Jin Wang,Ye Zhu,Tong Xu,Zhenhua Xu,Qiancheng Zhu,Jianfei Ge,Shuo Tian,Xiaolong Lin
标识
DOI:10.4103/1673-5374.387979
摘要
Abstract JOURNAL/nrgr/04.03/01300535-202407000-00037/figure1/v/2023-11-20T171125Z/r/image-tiff Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury. Fibroblast growth factor 21 can inhibit ferroptosis and promote neurofunctional recovery, while heme oxygenase-1 is a regulator of iron and reactive oxygen species homeostasis. The relationship between heme oxygenase-1 and ferroptosis remains controversial. In this study, we used a spinal cord injury rat model to show that the levels of fibroblast growth factor 21 in spinal cord tissue decreased after spinal cord injury. In addition, there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord injury. Further, heme oxygenase-1 aggravated ferroptosis after spinal cord injury, while fibroblast growth factor 21 inhibited ferroptosis by downregulating heme oxygenase-1. Thus, the activation of fibroblast growth factor 21 may provide a potential treatment for spinal cord injury. These findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury.
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