Novel insight into the role of sulfur dioxide in fruits and vegetables: Chemical interactions, biological activity, metabolism, applications, and safety

Sulfur dioxide (SO₂) are a category of chemical compounds widely used as additives in food industry. So far, the use of SO₂ in fruit and vegetable industry has been indispensable although its safety concerns have been controversial. This article comprehensively reviews the chemical interactions of SO₂ with the components of fruit and vegetable products, elaborates its mechanism of antimicrobial, anti-browning, and antioxidation, discusses its roles in regulation of sulfur metabolism, reactive oxygen species (ROS)/redox, resistance induction, and quality maintenance in fruits and vegetables, summarizes the application technology of SO₂ and its safety in human (absorption, metabolism, toxicity, regulation), and emphasizes the intrinsic metabolism of SO₂ and its consequences for the postharvest physiology and safety of fresh fruits and vegetables. In order to fully understand the benefits and risks of SO₂, more research is needed to evaluate the molecular mechanisms of SO₂ metabolism in the cells and tissues of fruits and vegetables, and to uncover the interaction mechanisms between SO₂ and the components of fruits and vegetables as well as the efficacy and safety of bound SO₂. This review has important guiding significance for adjusting an applicable definition of maximum residue limit of SO₂ in food.