Total synthesis of the reported structure of bioactive dibenzofuran natural product karnatakafuran B

In this study, the first total synthesis of the reported structure of karnatakafuran B was accomplished through an 11-step reaction sequence using an allene-mediated electrocyclization of a 6π electron system involving a benzofuran [b]-bond for the construction of a highly substituted dibenzofuran ring. The spectral data of the synthesized compound was not identical to that of the natural karnatakafuran B.