Circulating Biomarkers of Neurodegeneration and Risk of Cognitive Impairment

Strong associations of baseline circulating biomarkers of neurodegeneration with cognitive impairment over 12.2 years suggest that early pathologic brain changes can be detected noninvasively years before clinical symptoms of cognitive impairment. This relationship persisted after statistical adjustment for other risk factors. Possible clinical and research applications for these biomarkers merit intensive investigation.